Retrovirus Molecular Conjugates
نویسندگان
چکیده
منابع مشابه
Retrovirus molecular conjugates. A novel, high transduction efficiency, potentially safety-improved, gene transfer system.
Two significant barriers limit the use of amphotropic retrovirus for human gene transfer protocols: 1) low transduction efficiency in cells with low receptor expression and 2) safety concerns originating from the risk of formation and propagation of replication competent virus in vivo. In principle, if ecotropic retrovirus, which is incapable of infecting human cells, could be transiently modif...
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A tetrawalled and an octawalled molecular umbrella conjugate of amphotericin B (AmB) have been synthesized. Both conjugates exhibit high water solubility, a low tendency to aggregate, negligible hemolytic activity at 100 μM, and an ability to release a derivative of AmB under reducing conditions that exhibits high antifungal activity. Whereas the larger, octawalled conjugate shows slight adsorp...
متن کاملCorrection to Molecular Umbrella–Amphotericin B Conjugates
A ll sterols that appear on the right side of each molecular umbrella framework shown in the Abstract, Text, and Table of Contents should have been drawn with the natural stereochemistry of cholic acid shown below and not that of its enantiomer: This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations ...
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Antibody-drug conjugate (ADC), as a next generation of antibody therapeutics, is a combination of an antibody and a drug connected via a specialized linker. ADC has four action steps: systemic circulation, the enhanced permeability and retention (EPR) effect, penetration within the tumor tissue, and action on cells, such as through drug delivery system (DDS) drugs. An antibody with a size of ab...
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30 mAbs Volume 6 Issue 1 Antibody-drug conjugates (ADCs) represent an exciting and promising therapeutic approach for the treatment of cancers. The US Food and Drug Administration’s recent approval of brentuximab vedotin (Adcetris) in 2011 and trastuzumab emtansine (Kadcyla) in 2013 has brought a proof of the ADC concept in hematologic and solid tumors, respectively. The number of ADCs or immun...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m010318200